Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly.
نویسندگان
چکیده
This study shows that the Vibrio cholerae RTX toxin is secreted by a four-component type I secretion system (TISS) encoded by rtxB, rtxD, rtxE, and tolC. ATP-binding site mutations in both RtxB and RtxE blocked secretion, demonstrating that this atypical TISS requires two transport ATPases that may function as a heterodimer.
منابع مشابه
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عنوان ژورنال:
- Journal of bacteriology
دوره 186 23 شماره
صفحات -
تاریخ انتشار 2004